As part of a study released in Progress in Retinal and Eye Research, 113 patients were examined using Detection of Apoptosis in Retinal Cells (DARC) to detect areas of the eye indicative of the retinal disease geographic atrophy. The study was conducted by experts at Imperial College London. "DARC (Detection of Apoptosing Retinal Cells) is a retinal imaging technology that has been developed within the last 2 decades from basic laboratory science to Phase 2 clinical trials," according to the findings. "It uses ANX776 (fluorescently labelled Annexin A5) to identify stressed and apoptotic cells in the living eye. During its development, DARC has undergone biochemistry optimisation, scale-up and GMP manufacture and extensive preclinical evaluation."